Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents
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چکیده
منابع مشابه
Fetal hemoglobin in sickle cell anemia
Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin polymer. Fetal hemoglobin genes are genetically regulated, and the level of HbF and its distribution among sickle erythrocytes is highly variable. Some patients with sickle cell disease have exceptionally high level...
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THIS ISSUE OF BLOOD features a report by Atweh et al1 on the induction of fetal hemoglobin (Hb F) by pulse butyrate. This study is a solid addition to the recent and gratifying momentum in the development of effective therapy for sickle cell disease. Underlying this report is a series of novel and convincing in vivo studies extending from model systems in the chicken,2 sheep,3 and baboons4-6 to...
متن کاملFetal hemoglobin in sickle cell anemia: a glass half full?
Fetal hemoglobin (HbF) modulates the phenotype of sickle cell anemia by inhibiting deoxy sickle hemoglobin (HbS) polymerization. The blood concentration of HbF, or the number of cells with detectable HbF (F-cells), does not measure the amount of HbF/F-cell. Even patients with high HbF can have severe disease because HbF is unevenly distributed among F-cells, and some cells might have insufficie...
متن کاملFetal hemoglobin and hemolysis markers in sickle cell anemia☆
It has been known for many years that high levels of fetal hemoglobin (Hb F) have an important clinical benefit in patients with sickle cell anemia (SCA). This knowledge was initially based on the observation that populations of Indian and Arabian SCA patients with high Hb F levels have a milder clinical form of the disease.1 Later on, epidemiological studies demonstrated that patients with Hb ...
متن کاملFetal hemoglobin during infancy and in sickle cell adults.
BACKGROUND Fetal hemoglobin has been implicated in the modulation of sickle cell crisis though it is functional during infancy. OBJECTIVE The purpose of this study was to determine the waning time of fetal hemoglobin (HbF) and its persistence in later life. METHOD Ninety infants aged 0-12 months, admitted at hospital, were tested for their HbF levels. Adult patients numbering 690 were also ...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2016
ISSN: 0361-8609
DOI: 10.1002/ajh.24261